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Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire information online for “Tadalafil is safe for you to take ”To review whether or how to take Tadalafil t:

What information does the medicine provide?

You should be able to tell Tadalafil by its white lines, its white rings, its dyes (e.g. tashazol, tansy), its inactive ingredients, and the medicine’s branded manufacturer, as well as the manufacturer of its product.

Medicines are only considered as controlled substances if they are used to treat a condition other than the condition they are intended to prevent. You are advised to go to your GP or pharmacist for advice before taking Tadalafil.

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How to take it.

When you are taking this medication inform your GP about any that you have done since you are taking Tadalafil.

How often is it needed?

The advice of your GP will only be needed when required. Do not take more than one medication at a time in a single visit. If you take more than one medication at a time, communication with your doctor is required.

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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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  • : Cialis can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food Interactions:
    1. : Grapefruit can increase the levels of tadalafil by interfering with its metabolism. This medicine can amplify side effects like headaches, dizziness, or low blood pressure.
    2. : Though this combination may worsen side effects like headaches or increase heart rate in sensitive individuals, using it in conjunction with Cialis can enhance its effectiveness.
    3. : While this can help with symptoms, avoiding these foods and meals can increase the risk of side effects.
  • Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

    Common side effects reported from Cialis use include:

    • Headache
    • Indigestion
    • Heartburn
    • Upset stomach
    • Gas
    • Nausea
    • Flushing

    More severe side effects include:

    • Painful erections or erections that last longer than 4 hours
    • Sudden loss of vision
    • Sudden loss of hearing
    • Ringing in the ears
    • Chest pain
    • Shortness of breath
    • Painful urination
    • Increased urination frequency
    • Fainting
    • Dizziness
    • Skin rash
    • Hives
    • Facial swelling

    If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

    As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

    Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

    In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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    As with all prescription medications, be sure to inform your doctor of any medical conditions you currently manage.

    If you experience changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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    If we are not completely sure what is causing the problem, please speak with your doctor or pharmacist.

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    In addition, let your doctor know if you are pregnant or plan to become pregnant. Cialis can cause potentially serious dizziness or fainting during sex.

    As with all prescription medications, inform your doctor of any medical condition you currently manage.

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    This medication is available in 20mg and is taken orally. The dosage is based on your medical condition and response to treatment.